Figure 4. Pedigree of three-generation family. Females are represented by circles and males by squares. Ophthalmologist-confirmed affected individuals are colored black. Obligate carrier females are indicated by a black dot. Haplotypes of all genotyped individuals in the Xq24 region are shown with critical recombination events indicated by an arrowhead. The segregating haplotype is boxed. The alleles marked with an asterisk may represent a mutational event in female III:2 at marker DXS8055.