Figure 3 of Chen, Mol Vis 2008; 14:602-614.


Figure 3. Characterization of E2F1/E2F5 bigenic eyes at E14.5. When compared with FVB lens (A), the bigenic lens histology shows alterations in fiber cell elongation, and the presence of extra nuclei in the center of the lens (B), similar to the lens phenotype in the E2F1 single transgenic lens [29]. There are no BrdU positive fiber cells (brown nuclear stain) in the FVB lens (C). BrdU positive fiber cells were prevalent in the double transgenic lens (D). Abbreviations: le, lens epithelium; lf, lens fiber. Scale bars=500 μm.