Table 5 of Ueta, Mol Vis 2008; 14:550-555.

Table 5. HLA-DQB1 alleles and SJS/TEN with ocular complications.

HLA-DQB1 alleles Carrier frequency Allele frequency
SJS (n=71) Normal (n=113) p Odds ratio SJS (n=142) Normal (n=226) p Odds ratio
*0201 0.014 0.009 1 - 0.007 0.004 1 -
(1/71) (1/113) (1/142) (1/226)
*0301 0.254 0.212 0.52 - 0.141 0.106 0.32 -
(18/71) (24/113) (20/142) (24/226)
*0302 0.169 0.177 0.89 - 0.085 0.093 0.78 -
(12/71) (20/113) (12/142) (21/226)
*0303 0.296 0.354 0.41 - 0.169 0.195 0.54 -
(21/71) (40/113) (24/142) (44/226)
*0401 0.197 0.239 0.51 - 0.106 0.128 0.51 -
(14/71) (27/113) (15/142) (29/226)
*0402 0.056 0.053 1 - 0.028 0.027 1 -
(4/71) (6/113) (4/142) (6/226)
*0501 0.113 0.097 0.81 - 0.056 0.053 1 -
(8/71) (11/113) (8/142) (12/226)
*0502 0 0.08 0.01 0 0 0.04 0.01 0
(0/71) (9/113) (0/142) (9/226)
*0503 0.085 0.062 0.57 - 0.042 0.031 0.57 -
(6/71) (7/113) (6/142) (7/226)
*0601 0.352 0.274 0.26 - 0.19 0.164 0.63 -
(25/71) (31/113) (26/142) (37/226)
*0602 0.155 0.106 0.33 - 0.078 0.058 0.45 -
(11/71) (12/113) (11/142) (13/226)
*0603 0.014 0.009 1 - 0.007 0.004 1 -
(1/71) (1/113) (1/142) (1/226)
*0604 0.169 0.195 0.66 - 0.085 0.097 0.68 -
(12/71) (22/113) (12/142) (22/226)

HLA-DQB1*0502 showed a tendency of negative association with SJS/TEN with ocular complications (carrier frequency: p<0.05, Pc=0.17, OR=0; allele frequency: p<0.05, Pc=0.19, OR=0). Although none of the 71 SJS/TEN patients and 10 of the 117 healthy volunteers (8.5%) had the HLA-DQB1*0502 allele, the correction of the p-value for the number of alleles detected (n=14) rendered the result not significant.

Ueta, Mol Vis 2008; 14:550-555. http://www.molvis.org/molvis/v14/a67

©2008 Molecular Vision http://www.molvis.org/molvis/

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