Molecular Vision: Ueta, Mol Vis 2008; 14:550-555. Table 1

Table 1. HLA-A alleles and SJS/TEN with ocular complications.

HLA-A alleles	Carrier frequency				Allele frequency
HLA-A alleles	SJS (n=71)	Normal (n=113)	p-value (Χ²)	Odds ratio	SJS (n=142)	Normal (n=226)	p-value (Χ²)	Odds ratio
*0101	0	0.035	0.16	-	0	0.018	0.3	-
	(0/71)	(4/113)			(0/142)	(4/226)
*0201	0.268	0.221	0.47	-	0.155	0.111	0.22	-
	(19/71)	(25/113)			(22/142)	(25/226)
*0206	0.423	0.15	0.00004	4.1	0.225	0.084	0.0001	3.2
	(30/71)	(17/113)	*		(32/142)	(19/226)	*
*0207	0.07	0.08	1	-	0.035	0.04	1	-
	(5/71)	(9/113)			(5/142)	(9/226)
*0301	0.014	0	0.39	-	0.007	0	0.39	-
	(1/71)	(0/113)			(1/142)	(0/226)
*1101	0.056	0.204	0.005	0.23	0.028	0.115	0.003	0.22
	(4/71)	(23/113)			(4/142)	(26/226)	*
*2402	0.521	0.566	0.55	-	0.296	0.332	0.47	-
	(37/71)	(64/113)			(42/142)	(75/226)
*2601	0.099	0.115	0.81	-	0.049	0.062	0.65	-
	(7/71)	(13/113)			(7/142)	(14/226)
*2602	0.056	0.035	0.49	-	0.028	0.018	0.49	-
	(4/71)	(4/113)			(4/142)	(4/226)
*2603	0.014	0.027	1	-	0.007	0.013	1	-
	(1/71)	(3/113)			(1/142)	(3/226)
*3001	0.014	0.009	1	-	0.007	0.004	1	-
	(1/71)	(1/113)			(1/142)	(1/226)
*3101	0.099	0.186	0.14	-	0.049	0.093	0.16	-
	(7/71)	(21/113)			(7/142)	(21/226)
*3303	0.225	0.212	0.84	-	0.113	0.111	0.95	-
	(16/71)	(24/113)			(16/142)	(25/226)

HLA-A*0206 was strongly associated with SJS/TEN with ocular complications (carrier frequency: p<0.00005, corrected p value (Pc)<0.0005, OR=4.1; allele frequency: p<0.0005, Pc<0.005, OR=3.2). HLA-A*1101 was inversely associated (carrier frequency: p<0.01, Pc=0.07, OR=0.23; allele frequency: p<0.005, Pc<0.05, OR=0.22). SJS/TEN patients in this study consisted of 40 previously analyzed patients and 31 new patients. These results validate the strong association between HLA-A*0206 and SJS/TEN that we reported previously [13].