Table 5 of Aragon-Martin, Mol Vis 2008; 14:533-541. Table 5 of Aragon-Martin, Mol Vis 2008; 14:533-541.
Table 5. Estimated two- and three-loci haplotype frequencies for three LOXL1 SNPs and their corresponding association tests between exfoliation syndrome and controls.
| SNP1 alleles | SNP2 alleles | XFS | Controls | Association tests between exfoliation and controls | |||
| rs1048661 | rs3825942 | n=566 | n=658 | p-Values | Odds (95% C.I.) | AR% | PAR% |
| G | G | 0.8021 | 0.503 | 1.47x10−27 | 4.00 (3.10–5.18) | 37 | 22 |
| T | G | 0.1572 | 0.2964 | 9.01x10−9 | 0.44 (0.33–0.59) | 88 | 28 |
| G | A | 0.0406 | 0.2006 | 4.83x10−17 | 0.17 (0.11–0.27) | 394 | 58 |
| rs1048661 | rs2165241 | n=560 | n=650 | p-Values | Odds (95% C.I.) | AR% | PAR% |
| G | T | 0.7284 | 0.4362 | 1.29x10−24 | 3.46 (2.71–4.41) | 40 | 24 |
| T | C | 0.1499 | 0.287 | 1.14x10−8 | 0.44 (0.33–0.58) | 91 | 28 |
| G | C | 0.1126 | 0.2653 | 2.26x10−11 | 0.35 (0.26–0.48) | 135 | 36 |
| T | T | 0.0091 | 0.0115 | 0.6812 | 0.83 (0.26–2.62) | 21 | 9 |
| rs3825942 | rs2165241 | n=560 | n=654 | p-Values | Odds (95% C.I.) | AR% | PAR% |
| G | T | 0.7364 | 0.4458 | 2.02x10−24 | 3.45 (2.71–4.40) | 39 | 23 |
| G | C | 0.2266 | 0.3547 | 1.16x10−6 | 0.53 (0.41–0.69) | 56 | 20 |
| A | C | 0.037 | 0.1995 | 1.49x10−17 | 0.16 (0.10–0.25) | 430 | 60 |
| Combined haplotypes* | n=566 | n=666 | p-Values | Odds (95% C.I.) | AR% | PAR% | |
| GGT | 0.7278 | 0.4382 | 1.93x10−24 | 3.43 (2.69–4.36) | 40 | 23 | |
| GAC | 0.0346 | 0.1973 | 4.99x10−18 | 0.15 (0.09–0.24) | 457 | 60 | |
| TGC | 0.1486 | 0.2877 | 5.82x10−9 | 0.43 (0.32–0.57) | 94 | 29 | |
| GGC | 0.0795 | 0.0661 | 0.3693 | 1.22 (0.79–1.88) | 17 | 9 | |
| TGT | 0.0097 | 0.0107 | 0.8595 | 0.84 (0.26–2.66) | 19 | 8 | |