Table 1. Stained positive area of experimental and control groups (mean±SD)

There was significant difference in stained positive areas on the ON sections between experimental(Nogo-A/B/C knockout mice) and control groups (C57BL/6 control mice). The positive area of GAP-43 stain of the experimental group increased significantly from one day to seven days after crush. There was little increase of the positive area of GAP-43 stain of the control group. Comparison at first post-injury day, *p<0.01; comparison at seventh day, **p<0.01.(asterisk means positive area of stain of experimental group and control group at first post-injury day, double asterisk means positive area of stain of experimental group and control group at seventh day).

         Positive area of      Positive area of
             stain of             stain of
Time    experimental group   experimental group
(day)       (102μm2)             (102μm2)          t      p
-----   ------------------   ------------------   ----   -----
  1       5.06±0.26             0.36±0.05*         2.59  <0.01
  3       16.28±1.29            0.52±0.09          3.12  <0.01
  7       26.32±2.56**          0.88±0.25**        3.95  <0.01
          F                     45.36              2.85  <0.01
          p                     <0.01             <0.005