Figure 2. St. John’s Wort and hypericin inhibit retinal neovascularization. Quantification of neovascularization (A) and vasoobliteration (B) was performed after gavage treatment with either 15 mg/kg/day St. John’s Wort (SJW; n=18), 15 µg/kg/day hypericin (n=12), 45 µg/kg/day hypericin (n=18), 135 µg/kg/day hypericin (n=12), or vehicle (n=24). The percentages of retinal neovascularization and vasoobliteration were quantified by comparing the number of pixels in the affected areas with the total number of pixels in the retina. Data are presented as mean ± SEM. Asterisk (*) indicates p<0.01 versus vehicle treatment. Double asterisk (**) denotes p<0.05 versus hypericin (15 µg/kg/day) treatment. N.S. means the data was not statistically significant.