Figure 1. St. John’s Wort and hypericin inhibit ischemia-induced retinal vessel formations. Shown are representative photographs of retinas stained with isolectin B4. Mice at P7 were reared in 75% oxygen for five days followed by room air for five days. St. John’s Wort (B) (SJW; 15 mg/kg/day), hypericin (C) (45 µg/kg/day), and vehicle (A) were administered to mice by gavage from P12 to p17. Retinas were isolated and stained with isolectin B4 to detect vasoobliteration and neovascularization. Magnification is X 5.