Molecular Vision: Paget, Mol Vis 2008; 14:2566-2574. Table 1

Table 1. Parametric models used in the parametric multipoint genome-wide linkage analysis.

Phenocopy rates and penetrances
	DD	Dd	dd	Model
Autosomal recessive models	0	0	0.58	Model 1
	0	0	0.9	Model 2
Autosomal dominant models	0	0.58	0.58	Model 3
	0	0.9	0.9	Model 4
Autosomal additive models	0.1	0.58	0.58	Model 5
	0.1	0.9	0.9	Model 6
	0.2	0.58	0.58	Model 7
	0.2	0.9	0.9	Model 8

Based on the postulation of a single, two-allele gene in which “d” would be the disease-causing allele, eight parametric models have been tested. Models one and two assume an autosomal recessive mode of inheritance. Models three and four assume an autosomal dominant mode of inheritance. Models six to eight assume autosomal additive transmission as per Chen et al. [30]. In all models, penetrances of the genotype of 0.58 and 0.90 were used according to those reported respectively by Naiglin et al. [28] or Young et al. [23,27]. In addition, models five to eight consider ten or twenty percent phenocopy rates.