Figure 1. Schematic representation of Adenoviral vectors. A: This is a schematic diagram illustrating the cellular receptors for Ad5 and Ad35-based vectors with Ad35 vector containing the RGD motif inserted in the HI loop of the fiber knob. B: This is a schematic representation of wild-type adenovirus and an adenovector demonstrating the E1, E4 and partial E3 deletion (Ad5), or E1 only deletions (Ad35) with a SV40 poly A stop sequence, transgene (GFP, Luciferase, or PEDF) cDNA, and a human CMV promoter.