Table 4 of Fan, Mol Vis 2008; 14:2484-2491.

Table 4. Gene-based association of homocysteine genes with PXFS.

Gene SNPs p value
Haplotype test* Set-based test#
MTHFR rs1801131, rs1801133, rs17037396 0.97 1.00
MTR rs12096955, rs2229274, rs1805087 0.68 1.00
MTRR rs326122, rs1532268, rs161870, rs162036 0.85 0.19
MTHFD1 rs8006686, rs2236225, rs11627387 0.30 0.04
CBS rs2124459, rs1801181, rs5742905, rs234715 0.23 1.00

The asterisk indicates that the p values were obtained from the omnibus haplotype test using PLINK (version 1.04) [30] and the the sharp (hash mark) indicates that the p values were obtained from the set-based test by a permutation of 10,000 times using PLINK (version 1.04) [30]. The Bonferroni corrected significance level was 0.01 (0.05/5).

Fan, Mol Vis 2008; 14:2484-2491. http://www.molvis.org/molvis/v14/a286

©2008 Molecular Vision http://www.molvis.org/molvis/

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