Figure 3. Pedigrees of 13 Hungarian families with XLRS and identified mutations in the RS1 gene. Black boxes represent affected males, while circles with a black dot in the center represent carrier females by sequence analysis. Circles with an open dot represent females those who are expected to be obligate carrier females. Red arrows point to probands. Slashed boxes are deceased family members. Blue stars mark family members who underwent complete clinical examinations. The mutation screening of RS1 was performed in all family members except probable XLRS carriers, who did not want or could not take part in the study. Patients II:2 and II:3 in family 2 are fraternal twins, while patients II:3 and II:4 in family 12 are identical twins.