Figure 6. Reprogrammed cells showed responses to exogenous glutamate. A, B: The ΔF/Fo of each of two reprogrammed cells in an retinal pigment epithelium (RPE) cell culture infected with Replication Competent Avian Splice (RCAS)-achaete-scute homolog 1 (ash1) was plotted against time (in seconds) to produce response curves. C, D: The ΔF/Fo of each of two retinal cells in an E16 chick retinal cell culture was plotted against time (in seconds) to produce response curves as reference to those of reprogrammed cells. E, F: The ΔF/Fo of each of two RPE cells in the control culture infected with RCAS was plotted against time to produce response curves as negative controls. While no responses were observed with RPE cells, reprogrammed cells responded to glutamate and the response curves were similar to that of retinal cells. The arrow in each plot points to the time at which the neurotransmitter was applied.