Figure 1. Kindred structure and segregation of the STR markers in the family. Genotyping results for short tandem repeat (STR) markers, D4S402, D4S427, GATA30B11, which tightly encompassed BBS7, are shown below each individual. The disease alleles of the STR markers and the mutation of BBS7 are completely co-segregated with the phenotype of family. Affected individuals are identified by solid squares (males) or solid circles (females). Normal individuals are identified by open symbols; carry individuals are identified by open symbols with a dot inside; deceased individuals are indicated by a slash(/). Arrow indicates the proband of the family. M, mutant allele of BBS7; +, normal allele of BBS7.