Figure 8. Effect of TNF-α on the subcellular distribution of the trans-golgi network protein-2. Trans-golgi network protein-2 was found to decrease in the extracellular space and increase in the microsomal fraction in TNF-α-treated ARPE-19 cells (dark bars) when compared to untreated ARPE-19 cells (clear bars). This strongly suggests that TNF-α influences trans-golgi network protein-2 trafficking in ARPE-19 cells.