Figure 4. Roles of TGF-β related signaling on the spreading of the corneal endothelium in organ culture. The p38 inhibitor, SB203580, and the MAPK inhibitor, U0126, hindered endothelium sheet elongation (inhibition: SB203580>U0126). Neither the JNK inhibitor nor the ALK5 inhibitor, SB431542, (blocking Smad2/3 signal) have a significant effect on its repair.