Table 1 of Kim, Mol Vis 2008; 14:2109-2116. Table 1 of Kim, Mol Vis 2008; 14:2109-2116.
Table 1. Polymorphic sites of IL1A, IL1B, and IL1RN.
| Nucleotide | SNPs | dbSNPs | Amino acid | Assay methoda | Genotypesb | ||
|---|---|---|---|---|---|---|---|
| IL1A | |||||||
| exon 1 | −889 C>T | Ex1+12C>T | rs1800587 | RFLP: DpnII | *c: 170bp | *t: 145+25bp | |
| exon 5 | +4845 G>T | Ex5+21G>T | rs17561 | A114S | RFLP: SatI | *G:29+123+3+84bp | *T:152+3+84bp |
| intron 6 | +376 C>A | IVS6+169C>A | rs2071376 | RFLP: BstYI | *c:270bp | *a: 198+72bp | |
| IL1B | |||||||
| promoter | −511C>T | −511T>C | rs16944 | RFLP: AvaI | *t:530bp | *c:190+340bp | |
| promoter | −31 T>C | −31 C>T | rs1143627 | Direct sequencing | |||
| intron 4 | +5810 G>A | IVS4–64G>A | rs1143633 | RFLP: Fnu4HI | *g:38+271+19bp | *a:309+19bp | |
| exon 5 | +3954C>T | Ex5+14C>T | rs1143634 | F105F | RFLP: TaqI | *C:116+212bp | *T:328bp |
| IL1RN | |||||||
| exon 4 | +8006 C>T | EX4+55C>T | rs419598 | A60A | RFLP: HpaII | *C: 29 +98 bp | *T: 127 bp |
| intron 4 | +8061 C>T | IVS4+21C>T | rs423904 | RFLP: MwoI | *c:179+46bp | *t:225bp | |
| intron 4 | 86bp VNTR | Agarose | I: 410 bp,
II: 240bp, III: 500bp, IV: 325 bp, V: 595 bp |
||||
| intron 5 | +9589A>T | IVS5+59A>T | rs454078 | RFLP: SspI | *a:299bp | *t:145+154bp | |
| exon 7 | +11100T>C | Ex7+72T>C | rs315952 | S133S | RFLP: MspA1I | *T:330bp | *C:132+198bp |