Figure 6. Profile of circulating autoantibodies to glycated crystallins in human serum. A: Profile of circulating autoantibodies to HMW+α-glycated crystallins in serum during aging with respect to cataractogenesis as determined by antibody capture assay using polyclonal antibodies raised against human total lens proteins. Values are mean±SD at every given time point (n=5). The asterisk indicates that p<0.05, and the double asterisk indicates that p<0.001. N-apparently normal subjects; P-cataract patients. B: Profile of circulating autoantibodies to β-glycated crystallins in serum during aging with respect to cataractogenesis as determined by antibody capture assay using polyclonal antibodies raised against human total lens proteins. Values are mean±SD at every given time point (n=5). The asterisk indicates that p<0.05, and the double asterisk indicates that p<0.001. N-apparently normal subjects; P-cataract patients. C: Profile of circulating autoantibodies to γ-glycated crystallins in serum during aging with respect to cataractogenesis as determined by antibody capture assay using polyclonal antibodies raised against human total lens proteins. Values are mean±SD at every given time point (n=5). The asterisk indicates that p<0.05, and the double asterisk indicates that p<0.001. N-apparently normal subjects; P-cataract patients.