Table 4 of Shiels, Mol Vis 2008; 14:2042-2055.

Table 4. Position specific score matrix (PSSM) analysis of the predicted p.G948W substitution in EPHA2.


Codon		 Amino
acid		 Side-
chain
Charge		 Potential
H-bonds		 Residue
weight		 Isoelectric
point		 Hydro-
phobicity		 PSSM
value
GGG G (Gly) -H 0 0 57 6.0 0.770 6
TGG W (Trp) -CH2-C8
H4NH		 0 1 186 5.9 0.854 −6

Differences in the physico-chemical properties of glycine and tryptophan are consistent with a non-conservative substitution. The negative PSSM value indicates that tryptophan substitutes for glycine at position 948 less frequently than expected among proteins containing the conserved SAM domain.

Shiels, Mol Vis 2008; 14:2042-2055. http://www.molvis.org/molvis/v14/a241

©2008 Molecular Vision http://www.molvis.org/molvis/

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