Molecular Vision: Behndig, Mol Vis 2008; 14:2025-2030. Table 1

Table 1. Summary of corneal endothelial morphology at older ages in mice lacking superoxide dismutase 1 and/or 3 and in C57BL/6 wild type controls.

Mouse type	Age (months)	A (µm²)	HSF (A.U.)	DE (A.U.)	P (µm)	CV	n=
Wild type	10.4±3.0	246±35	1.30±0.40	0.19±0.02	58±4	0.35±0.027	6
SOD-3 null	10.9±3.0	353±56*	1.35±0.23	0.19±0.02	69±6*	0.35±0.064	6
SOD-1/3 null	11.8±2.1	360±95*	1.39±0.20	0.19±0.02	69±9*	0.30±0.032	6
SOD-1 null	12.1±0.0	273±25	1.35±0.24	0.19±0.02	61±3	0.36±0.018	6
Wild type	61.8±18.5	494±57	1.30±0.32	0.14±0.02	84±5	0.24±0.036	36
SOD-3 null	57.5±27.0	637±121*	1.45±0.29	0.14±0.02	91±8*	0.23±0.051	29
SOD-1/3 null	49.9±5.8	619±67*	2.21±0.75*	0.19±0.06*	98±6*#	0.31±0.057*#	21
SOD-1 null	64.9±22.3	504±74	1.36±0.27	0.14±0.02	83±6	0.26±0.038	32

A=mean cell area; HSF=hexagon shape factor (quantifying the deviation from the ideal hexagonal cell shape); DE=degree of cell elongation; P=mean cell perimeter; CV= coefficient of variation, expressing the degree of cell polymegethism; A.U.=arbitrary units. The asterisk indicates that there was significant difference from the corresponding wild type control, and the sharp (hash mark) signified that there was significant difference from the SOD-3 null genotype. The absence of SOD-3 leads to larger cells, and in the absence of SOD-3 and SOD-1, the cells also become more irregular with increased pleomorphism and polymegethism as the mice age.