Figure 1. Family pedigrees. Pedigrees of A) PKGL021, B) PKGL022 and C) PKGL026. Squares denote males while circles denote females. Filled symbols indicate affected individuals. A double line between individuals signifies consanguinity, and a diagonal line through a symbol indicates a deceased family member. The haplotypes of six adjacent chromosome 2p21 microsatellite markers are shown with alleles forming the risk haplotype shaded black, alleles cosegregating with PCG but not showing homozygosity shaded gray, and alleles not cosegregating with PCG shown in white.