Figure 4. DNA sequence chromatograms of PEO1 for unaffected and affected members in the family. A single transition was observed at position 1423 (G>A) of PEO1, causing a substitution of Ala to Thr at codon 475 (A475T). A table of phylogenetic conservation is also shown. Hs, Homo sapiens; MaMu, Macaca Mutallata; Mm, Mus musculus; Cf, Canis familiaris; Eq, Equus Caballus; Xl, Xenopus laevis, Dm, Drosophila melanogaster.