Figure 2. Photographs of irises from normal control, patients, and carriers. Both of eyes′ irises are presented. A is a normal person whose irises exhibited normal pigmentation. B shows the irises of proband (III:3) in family 2. He is the only one patient who had obvious iris hypopigmentation. Obvious hypopigmentation is observed in both of eyes in picture B. C is the proband (IV:1) of family 4, showing slightly hypopigmentation in peripheral of the both eyes. D is carrier (III:3) in family 4. Her iris hypopigmentation is also very mild in both of eyes.