Figure 3. Histological analysis of the effects of treatment with pSilencer^siVEGF on ischemia-induced retinal neovascularization. A: Postnatal day 17 (P17) retina from the eye of a hypoxic mouse injected with 1000 ng pSilencer null vector. Extensive preretinal neovascular loops are apparent (black arrows). B: P17 retina from the eye of hypoxic mouse injected with 1000 ng pSilencer^siVEGF. Preretinal neovascular loops were not as apparent, suggesting that treatment reduced preretinal neovascularization compared with the pSilencer null vector-injected eye. The following abbreviations were used in the figure: interlimiting membrane (ILM), ganglion cell layer (GCL), inner nuclear layer (INL), and outer nuclear layer (ONL).