Figure 4. Protein sequence conservation.
Diagram shows part of the amino acid sequence of the CERKL protein from
multiple species around the nuclear localization signal sequence (NLS),
which is represented as “KLKRR” in humans. Note the asterisk (*), which
marks the evolutionary conserved arginine (R) residue in the normal
sequence that is mutated to a serine in patients who go on to develop
retinal degeneration.