Figure 5. Expression of several known target genes of ETS-1 and ETS-2. ICAM-1, MCP-1, PAI-1, and p16 mRNA levels were evaluated by semi-quantitative RT–PCR and normalized using cyclophilin mRNA as a control. These mRNA levels were compared with those in control mice of the same age. In A, we observed that ICAM-1 is upregulated in Tyrp-1 model from p20 to 3 months. In B, we observed that MCP-1 is upregulated in Tyrp-1 model from p25 to 3 months. In C, we observed that PAI-1 is upregulated in Tyrp-1 model from p20 to 3 months. In D, we observed that p16 is upregulated in Tyrp-1 model from p25 to 3 months.