Figure 6. A single intravitreous ET-1
injection and elevation of intraocular pressure decreased thy-1 protein
levels in rat retinas. Thy-1 expressed by retinal ganglion cells is
widely used as marker for RGC early stress and was shown to be reduced
following ET injection and elevation of IOP by ~ 25%. Data are
expressed as a ratio of the control value and each column represents
mean±SEM. Densitometric quantification is shown in C and D.
The asterisk denotes statistical significance of thy-1 in ET-injected
retinas versus control (p<0.05) and the double asterisk denotes
statistical significance of thy-1 in elevated IOP-retinas versus
control (p<0.05) as determined by one-way ANOVA and Tukey multiple
comparison test. Abbreviations: control eye (C), ET-injected eye (E),
and elevated IOP (T).