Figure 4 of Dibas, Mol Vis 2008; 14:1770-1783.


Figure 4. Glial fibrillary acidic protein (GFAP) protein is upregulated following intravitreal ET-1 injection and elevation of intraocular pressure. Following retinal injuries with ET injection or elevation of IOP, retinas were dissected and cytosolic proteins were isolated. Fifty microgram protein was loaded into each lane. GFAP, a cellular marker for retinal injury, was upregulated in both injury models but with significant induction following ET injection (380+100%) compared to elevation of IOP (133+10%). Densitometric quantification is shown in C and D. Data are expressed as a ratio of the control value and each column represents mean±SEM. The asterisk denotes statistical significance of GFAP in ET-injected retinas versus control (p<0.005) and the double asterisk denotes statistical significance of GFAP in elevated IOP-retinas versus control (p<0.005), as determined by one-way ANOVA and Tukey multiple comparison test. Abbreviations: control eye (C), ET-injected eye (E), and elevated IOP (T).