Figure 10 of Dibas, Mol Vis 2008; 14:1770-1783.


Figure 10. Elevation of intraocular pressure decreased UCH-L1 mRNA levels. Total RNA was isolated and transcribed into cDNA. Real-time PCR was performed using specific primers (see Methods). mRNA expression of UCH-L1 was adjusted to the mRNA copies of β-actin (reference gene). Results indicate that mRNA expression level of UCH-L1 was significantly lower in elevated intraocular pressure (IOP) retinas compared to control. UCH-L1 commonly linked to other neurodegenerative diseases, may play a role in optic nerve degeneration. Data are expressed as a ratio of the control value and each column represents mean±SEM. The asterisk denotes statistical significance of ratio from IOP treatment versus that of control as determined by One-way ANOVA and Tukey multiple comparison test at p<0.05.