Figure 2. Gene schematic and linkage disequilibrium of genotyped SNPs. The gene schematic is taken from HapMap. Exons are displayed as boxes and introns as connecting lines, and untranslated regions are shaded gray. Linkage disequilibrium structure across CLU calculated in Haploview is shown. D′ values are given in the cell intersecting for each pair of SNPs. A blank cell indicates D′=1.0. The darker the cell, the greater the linkage disequilibrium between the SNPs. Haplotype blocks are outlined and were defined using the confidence interval method of Gabriel et al. [29].