Figure 1. Morphological changes of human
corneal epithelial cells infected with HSV-1. A: Normal human
corneal epithelial cells exhibited a cobblestone appearance. B:
The cytopathic effect could be seen at 8 h p.i. The space between
infected cells increased. After cells were infected with HSV-1 for 12 h
(C) and 24 h (D), the cobblestone appearance disappeared
and many giant multinucleated cells could be seen. Magnification: 200X.