Figure 1. Morphological changes of human corneal epithelial cells infected with HSV-1. A: Normal human corneal epithelial cells exhibited a cobblestone appearance. B: The cytopathic effect could be seen at 8 h p.i. The space between infected cells increased. After cells were infected with HSV-1 for 12 h (C) and 24 h (D), the cobblestone appearance disappeared and many giant multinucleated cells could be seen. Magnification: 200X.