Figure 3. Immunohistochemical staining with a γ-synuclein antibody was used to examine a non-glaucomatous human optic nerve in the area immediately posterior to the lamina cribrosa (A) and the retrobulbar optic nerve from a patient with primary open-angle glaucoma (B). In both sections, γ-synuclein reactivity can be seen along presumptive retinal ganglion cell axon bundles. In section B, arrows show swollen axons and axons fragment immunopositive for γ-synuclein. These results confirm the presence of γ-synuclein in axons of RGC and its immunopathology in glaucoma.