Figure 3. Detection of the Pro370Leu MYOC
mutation by direct polymerase chain reaction DNA sequencing in the GZ.1
pedigree. Representative chromatogram contains sequence from the
noncoding DNA strand. The location of the mutation within MYOC
and the nature of the nucleotide change (C->T ) were shown as a
double peak in the heterozygous condition.
![](images/mv-v14-1533-f3.jpg)