Figure 1. Pedigree structure of the Chinese family with 19 affected subjects in 5 generations. Squares indicate male subjects; circles, female subjects; solid symbols, affected family members with JOAG; unfilled symbols, unaffected family members; diagonal line, deceased individual. Arrow indicates the proband (III:7). According to the distribution of the affected members, the heredity of the GZ.1pedigree is autosomal dominant.