Figure 1. A four-generation pedigree illustrating affected and unaffected individuals. Either "+" or "–" denotes presence or absence of mutant allele, and denotes all the individuals examined. The three younger members of the pedigree (triplets) with the mutant allele were age 3 years at time of last examination, and appeared clinically unaffected. CDB=Bowman’s layer corneal dystrophy, PPCD=posterior polymorphous corneal dystrophy.