Figure 1. A four-generation pedigree
illustrating affected and unaffected individuals. Either "+" or "–"
denotes presence or absence of mutant allele, and denotes all the
individuals examined. The three younger members of the pedigree
(triplets) with the mutant allele were age 3 years at time of last
examination, and appeared clinically unaffected. CDB=Bowman’s layer
corneal dystrophy, PPCD=posterior polymorphous corneal dystrophy.