Molecular Vision: Kim, Mol Vis 2008; 14:1487-1492. Table 3

Table 3. Single factor conditional logistic regression analyses of risk factors for neovascular age-related macular degeneration

Variable	Risk Factor	Referent	O.R. (95% C.I.)	p value
SNP rs3093059*	CT or CC	TT	0.48 (0.16–1.46)	0.20
SNP rs2794521*	GA or GG	AA	1.02 (0.52–2.00)	0.95
SNP rs3093062	AG or AA	GG	1.23 (0.06–26.00)	0.90
SNP rs3091244*	CT, TT, CA, TA or AA	CC	0.74 (0.35–1.55)	0.42
SNP rs1417938*	TA or TT	AA	0.91 (0.46–1.80)	0. 78
SNP rs1800947*	CG or CC	GG	0.64 (0.17–2.43)	0. 51
SNP rs1130864*	TC or TT	CC	0.72 (0.36–1.45)	0.35
SNP rs1205*	AG or AA	GG	1.24 (0.64–2.42)	0.53
SNP rs3093068**	CC or CG	GG	0.57 (0.17–1.95)	0.37
CFH	CT or CC	TT	2.80 (1.17–6.70)	0.02
CFH	CC	CT or TT	31.62 (4.27–234.07)	0.0007
Smoking	≥10 pk-yrs	<10 pk-yrs	1.97 (1.12–3.46)	0.02
BMI^† 20s	≥25	<25	1.31 (0.61–2.81)	0.50
BMI^† 30s	≥25	<25	1.37 (0.70–2.70)	0.36
BMI^† 40s	≥25	<25	0.89 (0.49–1.64)	0.71
BMI^† 50s	≥25	<25	1.44 (0.76–2.75)	0.27
Overall BMI^†	≥25	<25	0.79 (0.43–1.45)	0.45
BMI^† 20s	(20-25)	≤20	1.09 (0.56–2.10)	0.81
BMI^† 30s	(20-25)	≤20	1.66 (0.66–4.16)	0.28
BMI^† 40s	(20-25)	≤20	3.41 (1.05–11.07)	0.04
BMI^† 50s	(20-25)	≤20	1.46 (0.39–5.52)	0.58
Overall BMI^†	(20-25)	≤20	2.78 (0.86–9.04)	0.09
BMI^† 20s	>25	<20	2.87 (0.47–17.5)	0.25
BMI^† 30s	>25	<20	N/A	N/A
BMI^† 40s	>25	<20	1.00 (0.14–7.10)	1.00
BMI^† 50s	>25	<20	N/A	N/A
Overall BMI^†	>25	<20	N/A	N/A
Diabetes^‡	Any type of diabetes	No diabetes	0.61 (0.27–1.39)	0.24

Single factor conditional logistic regression analyses of risk factors for neovascular age-related macular degeneration using SAS 9.1. Results from all nine genotyped single nucleotide polymorphisms are shown, including the seven that represent common genetic variation within CRP (as indicated by the *). The variable pk-yrs means pack-years, which was defined as one pack a day for one year. The OR is the odds ratio and C.I. is confidence interval. The variable BMI indicates body mass index, which was calculated by the mean weight in kilograms (excluding pregnancy or lactation) for each decade divided by the square of the height in meters at age 25 years. Decades shown are 20s, 30s, 40s, and 50s. Diabetes status (both insulin and non-insulin dependent), was defined by the regular use of medication as reported by the patient for at least six months before the reference age. N/A means not applicable, the sample size was too small when stratified. Results shown are based on 101 families, using one pair per family.