Figure 5. Global canonical pathway analysis of significantly upregulated and downregulated genes in minus lens-treated eyes as compared with plus lens-treated eyes. Data sets were analyzed by the Ingenuity Pathways Analysis software (Ingenuity^® Systems). The significance is expressed as a p value that is calculated using the right tailed Fisher exact test. Red and blue bars represent significantly upregulated and downregulated genes associated with canonical pathways, respectively. In the figure, n represents the number of genes identified in each of the pathways.