Figure 6. Frequency analysis of transcription response element representation in human first intron regions. Frequency of occurrence of each transcription response element (TRE) in the human gene first intron regions was determined from the PAINT analysis as described in Methods. The y-axis indicates the frequency of each TRE among the upregulated (blue) or down-regulated (green) gene clusters as well as among the full background gene set (black). The x-axis indicates the over-represented TREs, ordered by increasing p-value. Corresponding frequency analyses for mouse, rat and chick first intron regions are shown in Appendix 27 through Appendix 29.