Figure 4. Transcriptional regulatory network diagram for transcription response element associated with human first intron regions. The graphical representation was derived using GraphViz as described in Methods. The ellipses and diamonds represent individual genes divided into upregulated (blue) and down-regulated (green) clusters. The boxes represent TREs, with arrows indicating gene-TRE associations. Corresponding network diagrams for mouse, rat and chick first intron regions are shown in Appendix 21 through Appendix 23.