Figure 3. Transcriptional regulatory network diagram for transcription response element associated with human promoter regions. The graphical representation was derived using GraphViz as described in Methods. The ellipses and diamonds represent individual genes divided into upregulated (blue) and down-regulated (green) clusters. The boxes represent TREs, with arrows indicating gene-TRE associations. Corresponding network diagrams for mouse, rat and chick promoter regions are shown in Appendix 18 through Appendix 20.