Table 4 of Xu, Mol Vis 2008; 14:1373-1381.

Table 4. LOC387715 rs10490924 and HTRA1 rs11200638 genotype combination frequencies in patients with exudative AMD and control subjects



HTRA1


GG AG AA
AMD cases LOC387715 GG 13 (10.7%) 5 ( 4.1%) 0

TG 0 46 (38.0%) 3 ( 2.5%)

TT 0 1 ( 0.8%) 53 (43.8%)
Control subjects LOC387715 GG 37 (28.0%) 4 ( 3.0%) 0

TG 7 ( 5.3%) 58 (43.9%) 5 ( 3.8%)

TT 0 2 ( 1.5%) 19 (14.4%)
OR (95%CI) LOC387715 GG 1.0 (reference) 3.56 (0.83-15.30) -

TG - 2.26 (1.08-4.74) 1.71 (0.36-8.16)

TT - 1.42 (0.12-17.03) 7.94 (3.49-18.04)

This table shows the two-locus (LOC387715 and HTRA1) genotype combination frequencies in patients with exudative age-related macular degeneration (AMD) and control subjects. The combined presence of the risk LOC387715 TT genotype and HTRA1 AA genotype was more commonly found in cases than in controls and represented an increased risk for AMD. OR indicates odds ratio and CI refers to confidence interval.

Xu, Mol Vis 2008; 14:1370-1374. http://www.molvis.org/molvis/v14/a165

©2008 Molecular Vision http://www.molvis.org/molvis/

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