Figure 8. Electron micrographs obtained after transduction with HC Ad.VEGF-A. A: Nuclei of the choriocapillaris appeared extremely frayed or fragmented (asterisks). Remnants of the elastic layer of Bruch’s membrane can be recognized (arrows). B: Trombocytes (T) aggregated in the choriocapillaris. Cells (black asterisk) migrated into Bruch’s membrane between RPE and choriocapillaris. The elastic layer is marked by an arrow. C: Magnification of the frame in (B) showed that the adherent junctions were opened and the extracellular matrix had direct contact with the lumen of the capillary (arrow). D: The choriocapillaris was completely closed by thrombi (T), which was directly faced Bruch’s membrane (B). The endothelium (E) was thickened and interrupted by another cell (black asterisk). Scale bars in each image equal 1 μm.