Table 2 of Fuse, Mol
Vis 2008; 14:1338-1343. Table 2 of Fuse, Mol
Vis 2008; 14:1338-1343.
Table 2. Frequency of genotypes, p.R141L, p. G153D, and rs2165241, of LOXL1 in patients with XFS, XFG, and control subjects.
Genotype |
XFS all (n=56) |
XFG (n=36) |
XFS no glaucoma (n=20) |
POAG (n=62) |
Control (n=138) |
|---|---|---|---|---|---|
| LOXL1 p.R141L (rs1048661) variant | |||||
| T/T | 53 (94.6%) | 34 (94.4%) | 19 (95.0%) | 23 (37.1%) | 30 (21.7%) |
| T/G | 2 (3.6%) | 1 (2.8%) | 1 (5.0%) | 29 (46.8%) | 80 (58.0%) |
| G/G | 1 (1.8%) | 1 (2.8%) | 0 | 10 (16.1%) | 28 (20.3%) |
| p value* | 1.6x10−19 | 7.8x10−15 | 3.0x10−10 | 0.15 | |
| LOXL1 p.G153D (rs3825942) variant | |||||
| G/G | 56 (100%) | 36 (100%) | 20 (100%) | 51 (82.3%) | 108 (78.3%) |
| G/A | 0 | 0 | 0 | 11 (17.7%) | 26 (18.8%) |
| A/A | 0 | 0 | 0 | 0 | 4 (2.9%) |
| p value* | 7.5x10−4 | 8.8x10−3 | 0.068 | 0.58 | |
| LOXL1rs2165241 variant | |||||
| C/C | 54(96,4%) | 34(94.4%) | 20(100%) | 56(91.3%) | 122(88.4%) |
| C/T | 2(3.6%) | 2(5.6%) | 0 | 6(9.7%) | 16(11.6%) |
| T/T | 0 | 0 | 0 | 0 | 0 |
| p value* | 0.08 | 0.29 | 0.11 | 0.69 | |