Table 1 of Fuse, Mol
Vis 2008; 14:1338-1343. Table 1 of Fuse, Mol
Vis 2008; 14:1338-1343.
Table 1. LOXL1 allelic frequencies of rs1048661 and rs3825942 in Japanese patients with exfoliation syndrome and controls.
| SNP | p.R141L (rs1048661 G/T) | Odds ratio (95%CI) | p value | p.G153D (rs3825942 G/A) | Odds ratio (95% CI) | p value | |||
|---|---|---|---|---|---|---|---|---|---|
| Allele | T | G | G | A | |||||
| Japanese population in this study | |||||||||
| XFS all (n=56) | 0.964 | 0.036 | 26.0 (18.3–37.1) | 7.7x10−18 | 1 | 0 | - | 4.1x10−4 | |
| XFG (n=36) | 0.958 | 0.042 | 22.2 (15.9–30.9) | 1.7x10−12 | 1 | 0 | - | 5.2x10−3 | |
| XFS no glaucoma (n=20) | 0.975 | 0.025 | 37.9 (25.0–57.5) | 1.5x10−8 | 1 | 0 | - | 0.027 | |
| POAG (n=62) | 0.605 | 0.395 | 1.49 (1.25–1.78) | 0.11 | 0.911 | 0.089 | 1.43 (1.07–1.91) | 0.37 | |
| Control (n=138) | 0.507 | 0.493 | 0.877 | 0.123 | |||||
| Japanese population in the Western Japanese study* | |||||||||
| XFS all (n=59) | 0.992 | 0.008 | N/A | 3.0x10−19 | 1 | 0 | - | 1.4x10−5 | |
| XFG (n=27) | 1 | 0 | N/A | 1.1x10−10 | 1 | 0 | - | 3.0x10−3 | |
| XFS no glaucoma (n=32) | 0.984 | 0.016 | N/A | 1.7x10−11 | 1 | 0 | - | 1.3x10−3 | |
| Control (n=189) | 0.54 | 0.46 | 0.857 | 0.143 | |||||
| Icelandic population** | |||||||||
| XFG (n=75) | 0.173 | 0.827 | 2.56 (1.74–3.77) | 1.8x10−6 | 0.987 | 0.013 | 13.23 (5.59–31.29) | 4.1x10−9 | |
| XFS no glaucoma (n=55) | 0.211 | 0.789 | 2.02 (1.32–3.09) | 1.3x10−3 | 0.982 | 0.018 | 10.10 (4.02–25.36) | 8.5x10−7 | |
| POAG (n=90) | 0.289 | 0.711 | 1.32 (0.96–1.82) | 0.085 | 0.872 | 0.128 | 1.25 (0.81–1.91) | 0.32 | |
| Control (n=14,474) | 0.349 | 0.651 | 0.847 | 0.153 | |||||