Figure 1. The c.728G>A (Gly243Asp)
variation in CHX10. A: The wild type sequence is shown
on the left to compare with the variant CHX10 sequence on the
right. The comparison depicts the G>A transition that changed codon
243 from glycine (GGC) in the wild type sequence to aspartic acid (GAC)
in the variant CHX10 sequence. B: Protein alignment of
human (Homo sapiens) CHX10 (residues 215-261) is compared to
other CHX10-like proteins from other species, i.e., chimp (P.
troglodytes), mouse (M. musculus), rat (R.norvegicus),
chick (G. gallus), puffer fish (T. nigroviridis), and
worm (C. elegans). This comparison shows the conservation of the
glycine 243 residue in CHX10.