Figure 1 of Aung, Mol Vis 2008; 14:1313-1318.

Figure 1. The c.728G>A (Gly243Asp) variation in CHX10. A: The wild type sequence is shown on the left to compare with the variant CHX10 sequence on the right. The comparison depicts the G>A transition that changed codon 243 from glycine (GGC) in the wild type sequence to aspartic acid (GAC) in the variant CHX10 sequence. B: Protein alignment of human (Homo sapiens) CHX10 (residues 215-261) is compared to other CHX10-like proteins from other species, i.e., chimp (P. troglodytes), mouse (M. musculus), rat (R.norvegicus), chick (G. gallus), puffer fish (T. nigroviridis), and worm (C. elegans). This comparison shows the conservation of the glycine 243 residue in CHX10.