Table 3 of Mabuchi, Mol Vis 2008; 14:1303-1308.

Table 3. Demographic and clinical features of control subjects and primary open angle glaucoma patients with or without TT/GG compound genotype of rs1048661 and rs3825942 in LOXL1.


Control POAG
Feature TT/GG compound genotype
TT/GG compound genotype

+ (n=59) - (n=132) p value* + (n=59) - (n=154) p value*
Age at blood sampling (years) 64.0 ± 12.2 66.5 ± 11.0 0.16 63.2±14.9 62.8±14.8 0.88
Age at diagnosis (years) - - - 56.3±15.4 53.7±15.2 0.28
Male gender, n (%) 22 (37.3) 48 (36.4) >0.99 40 (67.8) 89 (57.8) 0.21
Familial history of glaucoma, n (%) 0 (0) 0 (0) 1 15 (25.4) 47 (30.5) 0.5
Refractive error (diopter) −0.45±2.2 −0.31±2.1 0.67 −2.2±3.2 −2.1±2.9 0.84
Maximum IOP (mmHg) 15.2 ± 2.6 14.9±2.8 0.55 27.4±6.0 28.9±9.9 0.27
History of laser trabeculoplasty, n (%) - - - 10 (16.9) 26 (16.9) >0.99
History of glaucoma surgery, n (%) - - - 18 (30.5) 48 (31.2) >0.99

No significant differences were noted in the demographic and clinical features of POAG patients as well as control subjects with and without the TT/GG compound genotype. Continuous variables are expressed as means±standard deviation. The asterisk indicates that the Student t-test or the Fisher's exact test was done. LOXL1: lysyl oxidase-like 1, POAG: primary open angle glaucoma, IOP: intraocular pressure.

Mabuchi, Mol Vis 2008; 14:1303-1308. http://www.molvis.org/molvis/v14/a156

©2008 Molecular Vision http://www.molvis.org/molvis/

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