Molecular Vision: Mabuchi, Mol Vis 2008; 14:1303-1308. Table 1

Table 1. Genotype and allele frequencies of rs1048661 and rs3825942 in patients with primary open angle glaucoma and exfoliation syndrome and control subjects.

SNP	Genotype/Allele	Control (n=191)	POAG (n=213)	p value*	XFS** (n=89)	p value*
rs1048661 (Arg141Leu)	Genotype
	TT (Leu/Leu)	59 (30.9)	59 (27.7)		88 (98.9)
	TG (Leu/Arg)	92 (48.2)	107 (50.2)	0.78	1 (1.1)	<0.0001
	GG (Arg/Arg)	40 (20.9)	47 (22.1)		0 (0)
	Allele
	T	210 (55.0)	225 (52.8)	0.57	177 (99.4)	<0.0001
	G	172 (45.0)	201 (47.2)		1 (0.6)
rs3825942 (Gly1153Asp)	Genotype
	AA (Asp/Asp)	8 (4.2)	6 (2.8)		0 (0)
	AG (Asp/Gly)	40 (20.9)	52 (24.4)	0.57	1 (1.1)	<0.0001
	GG (Gly/Gly)	143 (74.9)	155 (72.8)		88 (98.9)
	Allele
	A	56 (14.7)	64 (15.0)	0.92	1 (0.6)	<0.0001
	G	326 (85.3)	362 (85.0)		177 (99.4)

A significant difference in genotype frequencies of rs1048661 and rs3825942 was noted between XFS patients and control subjects. Frequencies of the T allele of rs1048661 and the G allele of rs3825942 were significantly higher in XFS patients than in control subjects. Data are given as numbers (percentage). The asterisk indicates that the χ² test or the Fisher's exact test was done. The double asterisk indicates that 67of 89 XFS patients had exfoliation glaucoma. POAG: primary open-angle glaucoma, XFS: exfoliation syndrome.