Figure 5. Structural modeling of the wild type and mutant γC-crystallins. The structure modeling is based on the X-ray determined coordinates of mouse γC-crystallin chain A using SWISS-MODEL. A: A structural model of the wild type γC-crystallin with 84% sequence identity is demonstrated. B: A structural alteration of the mutant γC-crystallin with 82% sequence identity is shown. Highly symmetric structure of γC-crystallin is disrupted when 66 amino acids are truncated from the COOH-terminus of γC-crystallin as result of c.327C>A mutation.