Table 3 of Rao, Mol Vis 2008; 14:1254-1262.
Table 3 of Rao, Mol Vis 2008; 14:1254-1262.
Table 3. Worldwide distribution of allele frequencies and their odds ratios for the three LOXL1 SNPs across all glaucoma phenotypes including the present cohort.
| Type of glaucoma | Phenotypes | Population [n cases] | rs1048661 (G) | rs3825942 (G) | rs2165241 (T) | Reference | ||||||
| Freq | OR (95% CI) | p value | Freq | OR (95%CI) | p value | Freq | OR (95%CI) | p value | ||||
| Primary | POAG | Iceland [n=90] | 0.711 | 1.32 (0.96–1.82) | 0.085 | 0.872 | 1.25 (0.81–1.91) | 0.32 | 0.55 | 1.36 (1.01–1.83) | 0.04 | [9] |
| POAG | Sweden [n=200] | 0.638 | 0.82 (0.61–1.10) | 0.19 | 0.863 | 0.87 (0.57–1.31) | 0.49 | 0.488 | 0.83 (0.63–1.09) | 0.18 | [9] | |
| POAG | India [n=112] | 0.616 | 0.70 (0.40–1.24) | 0.112 | 0.83 | 1.53 (0.78–2.98) | 0.105 | 0.321 | 0.95 (0.54–1.67) | 0.426 | [20] | |
| PACG | India [n=96] | 0.667 | 0.88 (0.49–1.59) | 0.332 | 0.755 | 0.94 (0.49–1.79) | 0.456 | 0.296 | 0.82 (0.45–1.50) | 0.262 | [20] | |
| POAG | USA [n=331] | 0.724 | 1.02 (0.70–1.51) | 0.92 | 0.771 | 0.86 (0.57–1.30) | 0.54 | 0.412 | 0.83 (0.59–1.18) | 0.33 | [12] | |
| POAG | Caucasians [n=279] | NA | NA | NA | 0.829 | NA | 0.583 | 0.424 | NA | 0.056 | [21] | |
| POAG | African-Americans [n=193] | NA | NA | NA | 0.617 | NA | 0.591 | 0.237 | NA | 0.408 | [21] | |
| POAG | Africans [n=170] | NA | NA | NA | 0.622 | NA | 0.217 | 0.226 | NA | 0.472 | [21] | |
| Secondary | XFS | Iceland [n=55] | 0.789 | 2.02 (1.32–3.09) | 1.3x10−3 | 0.982 | 10.1 (4.02–25.36) | 8.5x10−7 | 0.74 | 3.18 (2.12–4.76) | 1.9x10−8 | [9] |
| XFG | Iceland [n=75] | 0.827 | 2.56 (1.74–3.77) | 1.8x10−6 | 0.987 | 13.2 (5.59–31.29) | 4.1x10−9 | 0.753 | 3.40 (2.41–4.81) | 4.3x10−12 | [9] | |
| XFG | Sweden [n=199] | 0.834 | 2.39 (1.72–3.34) | 2.7x10−7 | 0.995 | 27.3 (11.4–65.07) | 9.1x10−14 | 0.813 | 3.78 (2.77–5.14) | 3.1x10−17 | [9] | |
| XFS | USA [n=72] | 0.819 | 3.03 (1.77–5.17) | 0.00003 | 0.986 | 9.68 (2.20–42.53) | 0.0003 | NA | NA | NA | [10] | |
| XFG | USA [n=50] | 0.787 | 1.86 (1.10–3.15) | 0.0222 | 0.939 | 3.05 (1.20–7.76) | 0.0194 | 0.667 | 2.30 (1.40–3.76) | 0.001 | [11] | |
| XFS/XFG | USA [n=206] | 0.829 | 1.90 (1.23–2.93) | 0.005 | 0.988 | 20.9 (8.06–54.39) | 1.6x10−15 | 0.76 | 3.77 (2.56–5.55) | 1.2x10−11 | [12] | |
| XFS/XFG | American and European [n=287] | 0.843 | 2.26 (1.71–2.99) | 7.74x10−9 | 0.959 | 5.97 (3.77–9.44) | 3.1x10−17 | 0.734 | 2.24 (1.76–2.86) | 4.8x10−24 | [13] | |
| XFS/XFG | Germany and Italy [n=726] | 0.82 | 2.43 (2.00–2.97) | 2.9x10−19 | 0.965 | 4.87 (3.46–6.85) | 8.2x10−23 | 0.765 | 3.42 (2.85–4.11) | 1.9x10−40 | [14] | |
| XFG | Europe [n=167] | 0.841 | 2.69 (1.59–4.54) | 9.91x10−19 | 0.994 | 37.29 (6.35–218.02) | 5.76x10−15 | NA | NA | NA | [18] | |
| XFS/XFG | India [n=50] | 0.72 | 1.49 (0.89–2.51) | 0.156 | 0.92 | 4.17 (1.89–9.18) | 0.0001 | NA | NA | NA | [15] | |
| XFS/XFG | Japan [n=59] | 0.008 | 1 | NA | NA | NA | [16] | |||||
| XFS/XFG | Japan [n=209] | 0.053 | 0.986 | 10.87 (4.59–27.25) | 1.30x10−11 | 0.017 | [19] | |||||
| XFS | Australia [n=86] | 0.78 | 1.86 (1.27–2.76) | 8.5x10−4 | 0.95 | 3.81 (1.88–9.02) | 7.8x10−5 | NA | NA | NA | [17] | |
| PG/PDS | USA [n=78] | 0.674 | 0.79 (0.49–1.25) | 0.309 | 0.852 | 1.24 (0.69–2.22) | 0.461 | 0.514 | 1.18 (0.77–1.81) | 0.432 | Present study | |