Table 1 of Wang, Mol Vis 2008; 14:105-113.

Table 1. Drug effects of gene expression of c-jun, c-fos, c-myc, caspase 3 and p53

Gene Treatment 0 min 10 min 20 min 30 min 50 min 80 min 2 h 12 h 24 h 48 h
c-jun 0.025% BA versus 0.0025% BA 0.88 0.051 0.003 <0.0005 0.003 0.009 0.105 0.002 0.602 0.059
c-jun 0.1 mg/ml TA versus 0.0025% BA 0.886 <0.0005 <0.0005 <0.0005 <0.0005 0.004 0.003 0.001 0.073 0.571
c-jun 1 mg/ml TA versus 0.025% BA 0.891 <0.0005 <0.0005 0.001 0.452 0.051 <0.0005 0.361 0.075 0.080
c-fos 0.025% BA versus 0.0025% BA 0.883 <0.0005 <0.0005 <0.0005 <0.0005 0.001 0.274 0.011 0.044 0.029
c-fos 0.1 mg/ml TA versus 0.0025% BA 0.960 <0.0005 <0.0005 <0.0005 0.149 0.423 0.368 0.114 0.358 0.969
c-fos 1 mg/ml TA versus 0.025% BA 0.660 <0.0005 0.002 <0.0005 <0.0005 0.002 0.245 0.933 0.607 0.072
c-myc 0.025% BA versus 0.0025% BA 0.715 0.090 0.490 0.005 <0.0005 0.461 0.152 0.060 0.070 0.006
c-myc 0.1 mg/ml TA versus 0.0025% BA 0.596 0.005 0.004 <0.0005 <0.0005 0.001 0.005 0.005 0.070 0.003
c-myc 1 mg/ml TA versus 0.025% BA 0.814 0.804 0.005 0.001 <0.0005 0.442 0.008 0.007 0.065 0.081
caspase 3 0.025% BA versus 0.0025% BA 0.902 0.683 0.089 0.070 1.000 0.041 0.154 0.024 0.099 0.033
caspase 3 0.1 mg/ml TA versus 0.0025% BA 1.000 0.054 0.114 0.024 0.04 0.01 0.001 <0.0005 0.002 <0.0005
caspase 3 1 mg/ml TA versus 0.025% BA 0.692 0.675 0.087 0.027 0.006 0.001 <0.0005 <0.0005 0.002 <0.0005
p53 0.025% BA versus 0.0025% BA 0.305 0.21 0.709 0.516 0.152 0.057 0.057 0.51 0.189 0.718
p53 0.1 mg/ml TA versus 0.0025% BA 0.678 0.067 0.059 0.25 0.003 0.001 <0.0005 <0.0005 <0.0005 <0.0005
p53 1 mg/ml TA versus 0.025% BA 0.219 0.065 0.026 0.1 0.001 0.001 <0.0005 0.007 <0.0005 <0.0005

The gene expressions of all five genes were significantly elevated in the TA-treated TM cells compared to corresponding benzyl alcohol-treated TM cells. However, except for p53, there were significantly different gene expressions of c-jun, c-fos, c-myc and caspase 3 between 0.025% and 0.0025% benzyl alcohol treatment. The numbers are the p values for the drug effects of gene expressions. BA indicates benzyl alcohol.

Wang, Mol Vis 2008; 14:105-113. http://www.molvis.org/molvis/v14/a13

©2008 Molecular Vision http://www.molvis.org/molvis/

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